affect vs have to do with

affect is a noun but have to do with is not a noun.

Word	Noun	Adjective	Verb	Adverb
affect	Yes	No	Yes	No
have to do with	No	No	Yes	No

As verbs, have to do with is a hypernym of affect; that is, have to do with is a word with a broader meaning than affect:

Other hypernyms of affect include bear on, come to, concern, pertain, refer, relate, touch, touch on.

affect (noun)	have to do with (noun)
the conscious subjective aspect of feeling or emotion

affect (verb)	have to do with (verb)
act physically on; have an effect upon	be relevant to
have an effect upon
make believe with the intent to deceive
have an emotional or cognitive impact upon
connect closely and often incriminatingly