heartsickness vs despondence

heartsickness and despondence both are nouns.

Word	Noun	Adjective	Verb	Adverb
heartsickness	Yes	No	No	No
despondence	Yes	No	No	No

As nouns, heartsickness and despondence are synonyms defined as:

heartsickness and despondence: feeling downcast and disheartened and hopeless

Other synonyms of heartsickness include despondency, disconsolateness.

heartsickness (noun)	despondence (noun)
feeling downcast and disheartened and hopeless	feeling downcast and disheartened and hopeless