acantholysis vs skin disease

acantholysis and skin disease both are nouns.

Word	Noun	Adjective	Verb	Adverb
acantholysis	Yes	No	No	No
skin disease	Yes	No	No	No

As nouns, skin disease is a hypernym of acantholysis; that is, skin disease is a word with a broader meaning than acantholysis:

acantholysis: a breakdown of a cell layer in the epidermis (as in pemphigus)
skin disease: a disease affecting the skin

Other hypernyms of acantholysis include disease of the skin, skin disorder.

acantholysis (noun)	skin disease (noun)
a breakdown of a cell layer in the epidermis (as in pemphigus)	a disease affecting the skin