acanthosis vs skin disease

acanthosis and skin disease both are nouns.

Word	Noun	Adjective	Verb	Adverb
acanthosis	Yes	No	No	No
skin disease	Yes	No	No	No

As nouns, skin disease is a hypernym of acanthosis; that is, skin disease is a word with a broader meaning than acanthosis:

acanthosis: an abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis)
skin disease: a disease affecting the skin

Other hypernyms of acanthosis include disease of the skin, skin disorder.

acanthosis (noun)	skin disease (noun)
an abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis)	a disease affecting the skin