bus route vs itinerary

bus route and itinerary both are nouns.

Word	Noun	Adjective	Verb	Adverb
bus route	Yes	No	No	No
itinerary	Yes	No	No	No

As nouns, itinerary is a hypernym of bus route; that is, itinerary is a word with a broader meaning than bus route:

Other hypernyms of bus route include path, route.

bus route (noun)	itinerary (noun)
the route regularly followed by a passenger bus	a proposed route of travel
	a guidebook for travelers
	an established line of travel or access