depressed vs low-spirited

depressed and low-spirited both are adjectives.

Word	Noun	Adjective	Verb	Adverb
depressed	No	Yes	No	No
low-spirited	No	Yes	No	No

As adjectives, depressed and low-spirited are synonyms defined as:

Other synonyms of depressed include blue, dispirited, down, down in the mouth, downcast, downhearted, gloomy, grim, low.

depressed (adjective)	low-spirited (adjective)
filled with melancholy and despondency	filled with melancholy and despondency
lower than previously
flattened downward as if pressed from above or flattened along the dorsal and ventral surfaces