emptiness vs worthlessness

emptiness and worthlessness both are nouns.

Word	Noun	Adjective	Verb	Adverb
emptiness	Yes	No	No	No
worthlessness	Yes	No	No	No

As nouns, worthlessness is a hypernym of emptiness; that is, worthlessness is a word with a broader meaning than emptiness:

Other hypernyms of emptiness include ineptitude.

emptiness (noun)	worthlessness (noun)
the quality of being valueless or futile	having no qualities that would render it valuable or useful
an empty area or space	the quality of being without practical use
the state of containing nothing
having an empty stomach