hindrance vs antagonism

hindrance and antagonism both are nouns.

Word	Noun	Adjective	Verb	Adverb
hindrance	Yes	No	No	No
antagonism	Yes	No	No	No

As nouns, antagonism is a hyponym of hindrance; that is, antagonism is a word with a more specific, narrower meaning than hindrance:

hindrance: the act of hindering or obstructing or impeding
antagonism: (biochemistry) interference in or inhibition of the physiological action of a chemical substance by another having a similar structure

Other hyponyms of hindrance include foiling, frustration, thwarting, obstruction, complication, deterrence, bar, prevention.

hindrance (noun)	antagonism (noun)
the act of hindering or obstructing or impeding	(biochemistry) interference in or inhibition of the physiological action of a chemical substance by another having a similar structure
any obstruction that impedes or is burdensome	an actively expressed feeling of dislike and hostility
something immaterial that interferes with or delays action or progress	the relation between opposing principles or forces or factors
	a state of deep-seated ill-will