irritant vs botheration

irritant and botheration both are nouns.

Word	Noun	Adjective	Verb	Adverb
irritant	Yes	No	No	No
botheration	Yes	No	No	No

As nouns, botheration is a hypernym of irritant; that is, botheration is a word with a broader meaning than irritant:

irritant: something that causes irritation and annoyance
botheration: something or someone that causes trouble; a source of unhappiness

Other hypernyms of irritant include annoyance, bother, infliction, nuisance, pain, pain in the ass, pain in the neck.

irritant (noun)	botheration (noun)
something that causes irritation and annoyance	something or someone that causes trouble; a source of unhappiness
	the psychological state of being irritated or annoyed