off his guard vs off her guard

off his guard and off her guard both are adjectives.

Word	Noun	Adjective	Verb	Adverb
off his guard	No	Yes	No	No
off her guard	No	Yes	No	No

As adjectives, off his guard and off her guard are synonyms defined as:

Other synonyms of off his guard include napping, off-guard, off guard, off one's guard, off your guard.

off his guard (adjective)	off her guard (adjective)
not prepared or vigilant	not prepared or vigilant