operate vs manipulate

operate and manipulate both are verbs.

Word	Noun	Adjective	Verb	Adverb
operate	No	No	Yes	No
manipulate	No	No	Yes	No

As verbs, manipulate is a hypernym of operate; that is, manipulate is a word with a broader meaning than operate:

operate (verb)	manipulate (verb)
perform surgery on	treat manually, as with massage, for therapeutic purposed
perform a movement in military or naval tactics in order to secure an advantage in attack or defense	hold something in one's hands and move it
handle and cause to function	maintain influence over (others or oneself) skillfully, usually to one's advantage
keep engaged	manipulate in a fraudulent manner
perform as expected when applied	influence or control shrewdly or deviously
direct or control; projects, businesses, etc.	tamper, with the purpose of deception