preference vs druthers

preference and druthers both are nouns.

Word	Noun	Adjective	Verb	Adverb
preference	Yes	No	No	No
druthers	Yes	No	No	No

As nouns, preference and druthers are synonyms defined as:

preference (noun)	druthers (noun)
grant of favor or advantage to one over another (especially to a country or countries in matters of international trade, such as levying duties)	the right or chance to choose
the right or chance to choose
a predisposition in favor of something
a strong liking