sissy vs effeminate

sissy is a noun but effeminate is not a noun.

Word	Noun	Adjective	Verb	Adverb
sissy	Yes	Yes	No	No
effeminate	No	Yes	No	No

As adjectives, sissy and effeminate are synonyms defined as:

Other synonyms of sissy include cissy, emasculate, epicene, sissified, sissyish.

sissy (noun)	effeminate (noun)
a timid man or boy considered childish or unassertive

sissy (adjective)	effeminate (adjective)
having unsuitable feminine qualities	having unsuitable feminine qualities