take issue vs negate

take issue and negate both are verbs.

Word	Noun	Adjective	Verb	Adverb
take issue	No	No	Yes	No
negate	No	No	Yes	No

As verbs, negate is a hyponym of take issue; that is, negate is a word with a more specific, narrower meaning than take issue:

Other hyponyms of take issue include dissent, clash, contradict, contravene.

take issue (verb)	negate (verb)
be of different opinions	make ineffective by counterbalancing the effect of
	prove negative; show to be false
	deny the truth of
	be in contradiction with