upshot vs response

upshot and response both are nouns.

Word	Noun	Adjective	Verb	Adverb
upshot	Yes	No	No	No
response	Yes	No	No	No

As nouns, response is a hyponym of upshot; that is, response is a word with a more specific, narrower meaning than upshot:

upshot (noun)	response (noun)
a phenomenon that follows and is caused by some previous phenomenon	a bodily process occurring due to the effect of some antecedent stimulus or agent
	the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
	the speech act of continuing a conversational exchange
	a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation
	the manner in which something is greeted
	a phrase recited or sung by the congregation following a versicle by the priest or minister
	a result