vade mecum vs guidebook

vade mecum and guidebook both are nouns.

Word	Noun	Adjective	Verb	Adverb
vade mecum	Yes	No	No	No
guidebook	Yes	No	No	No

As nouns, guidebook is a hyponym of vade mecum; that is, guidebook is a word with a more specific, narrower meaning than vade mecum:

vade mecum: a concise reference book providing specific information about a subject or location
guidebook: something that offers basic information or instruction

Other hyponyms of vade mecum include manual, bible, guide, ready reckoner, reckoner.

vade mecum (noun)	guidebook (noun)
a concise reference book providing specific information about a subject or location	something that offers basic information or instruction