whammy vs setback

whammy and setback both are nouns.

Word	Noun	Adjective	Verb	Adverb
whammy	Yes	No	No	No
setback	Yes	No	No	No

As nouns, setback is a hypernym of whammy; that is, setback is a word with a broader meaning than whammy:

whammy: a serious or devastating setback
setback: an unfortunate happening that hinders or impedes; something that is thwarting or frustrating

Other hypernyms of whammy include black eye, blow, reversal, reverse.

whammy (noun)	setback (noun)
an evil spell	an unfortunate happening that hinders or impedes; something that is thwarting or frustrating
a serious or devastating setback