despicable vs worthless

despicable and worthless both are adjectives.

Word	Noun	Adjective	Verb	Adverb
despicable	No	Yes	No	No
worthless	No	Yes	No	No

As adjectives, despicable and worthless are synonyms defined as:

Other synonyms of despicable include slimy, ugly, unworthy, vile, wretched.

despicable (adjective)	worthless (adjective)
morally reprehensible	lacking in usefulness or value
	morally reprehensible