difference vs departure

difference and departure both are nouns.

Word	Noun	Adjective	Verb	Adverb
difference	Yes	No	No	No
departure	Yes	No	No	No

As nouns, difference and departure are synonyms defined as:

difference and departure: a variation that deviates from the standard or norm

Other synonyms of difference include deviation, divergence.

difference (noun)	departure (noun)
the quality of being unlike or dissimilar	the act of departing
a disagreement or argument about something important	euphemistic expressions for death
a variation that deviates from the standard or norm	a variation that deviates from the standard or norm
the number that remains after subtraction; the number that when added to the subtrahend gives the minuend
a significant change