difference of opinion vs difference

difference of opinion and difference both are nouns.

Word	Noun	Adjective	Verb	Adverb
difference of opinion	Yes	No	No	No
difference	Yes	No	No	No

As nouns, difference of opinion and difference are synonyms defined as:

difference of opinion and difference: a disagreement or argument about something important

Other synonyms of difference of opinion include conflict, dispute.

difference of opinion (noun)	difference (noun)
a disagreement or argument about something important	the quality of being unlike or dissimilar
	a disagreement or argument about something important
	a variation that deviates from the standard or norm
	the number that remains after subtraction; the number that when added to the subtrahend gives the minuend
	a significant change