disregarding vs irrespective

disregarding and irrespective both are adverbs.

Word	Noun	Adjective	Verb	Adverb
disregarding	No	No	No	Yes
irrespective	No	No	No	Yes

As adverbs, disregarding and irrespective are synonyms defined as:

disregarding and irrespective: in spite of everything; without regard to drawbacks

Other synonyms of disregarding include disregardless, no matter, regardless.

disregarding (adverb)	irrespective (adverb)
in spite of everything; without regard to drawbacks	in spite of everything; without regard to drawbacks