irrespective vs disregarding

irrespective and disregarding both are adverbs.

Word	Noun	Adjective	Verb	Adverb
irrespective	No	No	No	Yes
disregarding	No	No	No	Yes

As adverbs, irrespective and disregarding are synonyms defined as:

irrespective and disregarding: in spite of everything; without regard to drawbacks

Other synonyms of irrespective include disregardless, no matter, regardless.

irrespective (adverb)	disregarding (adverb)
in spite of everything; without regard to drawbacks	in spite of everything; without regard to drawbacks