edema vs puffiness

edema and puffiness both are nouns.

Word	Noun	Adjective	Verb	Adverb
edema	Yes	No	No	No
puffiness	Yes	No	No	No

As nouns, puffiness is a hypernym of edema; that is, puffiness is a word with a broader meaning than edema:

edema: swelling from excessive accumulation of watery fluid in cells, tissues, or serous cavities
puffiness: an abnormal protuberance or localized enlargement

Other hypernyms of edema include lump, swelling.

edema (noun)	puffiness (noun)
swelling from excessive accumulation of watery fluid in cells, tissues, or serous cavities	lack of elegance as a consequence of being pompous and puffed up with vanity
	an abnormal protuberance or localized enlargement