puffiness vs edema

puffiness and edema both are nouns.

Word	Noun	Adjective	Verb	Adverb
puffiness	Yes	No	No	No
edema	Yes	No	No	No

As nouns, edema is a hyponym of puffiness; that is, edema is a word with a more specific, narrower meaning than puffiness:

puffiness: an abnormal protuberance or localized enlargement
edema: swelling from excessive accumulation of watery fluid in cells, tissues, or serous cavities

puffiness (noun)	edema (noun)
lack of elegance as a consequence of being pompous and puffed up with vanity	swelling from excessive accumulation of watery fluid in cells, tissues, or serous cavities
an abnormal protuberance or localized enlargement