extremity vs manus

extremity and manus both are nouns.

Word	Noun	Adjective	Verb	Adverb
extremity	Yes	No	No	No
manus	Yes	No	No	No

As nouns, manus is a hyponym of extremity; that is, manus is a word with a more specific, narrower meaning than extremity:

Other hyponyms of extremity include pedal extremity, vertebrate foot, hand, mitt, paw, finger, toe.

extremity (noun)	manus (noun)
an external body part that projects from the body	the (prehensile) extremity of the superior limb
that part of a limb that is farthest from the torso
the outermost or farthest region or point
the greatest or utmost degree
an extreme condition or state (especially of adversity or disease)