manus vs extremity

manus and extremity both are nouns.

Word	Noun	Adjective	Verb	Adverb
manus	Yes	No	No	No
extremity	Yes	No	No	No

As nouns, extremity is a hypernym of manus; that is, extremity is a word with a broader meaning than manus:

manus (noun)	extremity (noun)
the (prehensile) extremity of the superior limb	an external body part that projects from the body
	that part of a limb that is farthest from the torso
	the outermost or farthest region or point
	the greatest or utmost degree
	an extreme condition or state (especially of adversity or disease)