genetic constitution vs make-up

genetic constitution and make-up both are nouns.

Word	Noun	Adjective	Verb	Adverb
genetic constitution	Yes	No	No	No
make-up	Yes	No	No	No

As nouns, make-up is a hypernym of genetic constitution; that is, make-up is a word with a broader meaning than genetic constitution:

genetic constitution: the particular alleles at specified loci present in an organism
make-up: the way in which someone or something is composed

Other hypernyms of genetic constitution include composition, constitution, makeup, physical composition.

genetic constitution (noun)	make-up (noun)
the particular alleles at specified loci present in an organism	cosmetics applied to the face to improve or change your appearance
	the way in which someone or something is composed
	an event that is substituted for a previously cancelled event