issue vs placebo effect

issue and placebo effect both are nouns.

Word	Noun	Adjective	Verb	Adverb
issue	Yes	No	Yes	No
placebo effect	Yes	No	No	No

As nouns, placebo effect is a hyponym of issue; that is, placebo effect is a word with a more specific, narrower meaning than issue:

issue: a phenomenon that follows and is caused by some previous phenomenon
placebo effect: any effect that seems to be a consequence of administering a placebo; the change is usually beneficial and is assumed result from the person's faith in the treatment or preconceptions about what the experimental drug was supposed to do; pharmacologists were the first to talk about placebo effects but now the idea has been generalized to many situations having nothing to do with drugs

issue (noun)	placebo effect (noun)
the act of issuing printed materials	any effect that seems to be a consequence of administering a placebo; the change is usually beneficial and is assumed result from the person's faith in the treatment or preconceptions about what the experimental drug was supposed to do; pharmacologists were the first to talk about placebo effects but now the idea has been generalized to many situations having nothing to do with drugs
the act of providing an item for general use or for official purposes (usually in quantity)
an opening that permits escape or release
some situation or event that is thought about
an important question that is in dispute and must be settled
one of a series published periodically
the becoming visible
the immediate descendants of a person
a phenomenon that follows and is caused by some previous phenomenon
the income or profit arising from such transactions as the sale of land or other property
supplies (as food or clothing or ammunition) issued by the government

issue (verb)	placebo effect (verb)
come out of
prepare and issue for public distribution or sale
bring out an official document (such as a warrant)
make out and issue
circulate or distribute or equip with