placebo effect vs issue

placebo effect and issue both are nouns.

Word	Noun	Adjective	Verb	Adverb
placebo effect	Yes	No	No	No
issue	Yes	No	Yes	No

As nouns, issue is a hypernym of placebo effect; that is, issue is a word with a broader meaning than placebo effect:

placebo effect: any effect that seems to be a consequence of administering a placebo; the change is usually beneficial and is assumed result from the person's faith in the treatment or preconceptions about what the experimental drug was supposed to do; pharmacologists were the first to talk about placebo effects but now the idea has been generalized to many situations having nothing to do with drugs
issue: a phenomenon that follows and is caused by some previous phenomenon

Other hypernyms of placebo effect include consequence, effect, event, outcome, result, upshot.

placebo effect (noun)	issue (noun)
any effect that seems to be a consequence of administering a placebo; the change is usually beneficial and is assumed result from the person's faith in the treatment or preconceptions about what the experimental drug was supposed to do; pharmacologists were the first to talk about placebo effects but now the idea has been generalized to many situations having nothing to do with drugs	the act of issuing printed materials
	the act of providing an item for general use or for official purposes (usually in quantity)
	an opening that permits escape or release
	some situation or event that is thought about
	an important question that is in dispute and must be settled
	one of a series published periodically
	the becoming visible
	the immediate descendants of a person
	a phenomenon that follows and is caused by some previous phenomenon
	the income or profit arising from such transactions as the sale of land or other property
	supplies (as food or clothing or ammunition) issued by the government

placebo effect (verb)	issue (verb)
	come out of
	prepare and issue for public distribution or sale
	bring out an official document (such as a warrant)
	make out and issue
	circulate or distribute or equip with