profanation vs irreverence

profanation and irreverence both are nouns.

Word	Noun	Adjective	Verb	Adverb
profanation	Yes	No	No	No
irreverence	Yes	No	No	No

As nouns, irreverence is a hypernym of profanation; that is, irreverence is a word with a broader meaning than profanation:

profanation: blasphemous behavior; the act of depriving something of its sacred character
irreverence: a disrespectful act

Other hypernyms of profanation include violation.

profanation (noun)	irreverence (noun)
blasphemous behavior; the act of depriving something of its sacred character	a disrespectful act
degradation of something worthy of respect; cheapening	an irreverent mental attitude