profanation vs desecration

profanation and desecration both are nouns.

Word	Noun	Adjective	Verb	Adverb
profanation	Yes	No	No	No
desecration	Yes	No	No	No

As nouns, profanation and desecration are synonyms defined as:

profanation and desecration: blasphemous behavior; the act of depriving something of its sacred character

Other synonyms of profanation include blasphemy, sacrilege.

profanation (noun)	desecration (noun)
blasphemous behavior; the act of depriving something of its sacred character	blasphemous behavior; the act of depriving something of its sacred character
degradation of something worthy of respect; cheapening