burden vs significance

burden and significance both are nouns.

Word	Noun	Adjective	Verb	Adverb
burden	Yes	No	Yes	No
significance	Yes	No	No	No

As nouns, significance is a hypernym of burden; that is, significance is a word with a broader meaning than burden:

Other hypernyms of burden include import, meaning, signification.

burden (noun)	significance (noun)
weight to be borne or conveyed	the quality of being significant
the central idea that is expanded in a document or discourse	a meaning that is not expressly stated but can be inferred
an onerous or difficult concern	the message that is intended or expressed or signified
the central meaning or theme of a speech or literary work

burden (verb)	significance (verb)
impose a task upon, assign a responsibility to
weight down with a load