significance vs burden

significance and burden both are nouns.

Word	Noun	Adjective	Verb	Adverb
significance	Yes	No	No	No
burden	Yes	No	Yes	No

As nouns, burden is a hyponym of significance; that is, burden is a word with a more specific, narrower meaning than significance:

significance (noun)	burden (noun)
the quality of being significant	weight to be borne or conveyed
a meaning that is not expressly stated but can be inferred	the central idea that is expanded in a document or discourse
the message that is intended or expressed or signified	an onerous or difficult concern
	the central meaning or theme of a speech or literary work

significance (verb)	burden (verb)
	impose a task upon, assign a responsibility to
	weight down with a load