chemistry vs substance

chemistry and substance both are nouns.

Word	Noun	Adjective	Verb	Adverb
chemistry	Yes	No	No	No
substance	Yes	No	No	No

As nouns, substance is a hypernym of chemistry; that is, substance is a word with a broader meaning than chemistry:

chemistry (noun)	substance (noun)
the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions	the real physical matter of which a person or thing consists
the way two individuals relate to each other	a particular kind or species of matter with uniform properties
the chemical composition and properties of a substance or object	the property of holding together and retaining its shape
	the idea that is intended
	the choicest or most essential or most vital part of some idea or experience
	content communicating a message; what something is about
	considerable capital (wealth or income)
	material of a particular kind or constitution