substance vs substrate

substance and substrate both are nouns.

Word	Noun	Adjective	Verb	Adverb
substance	Yes	No	No	No
substrate	Yes	No	No	No

As nouns, substrate is a hyponym of substance; that is, substrate is a word with a more specific, narrower meaning than substance:

substance (noun)	substrate (noun)
the real physical matter of which a person or thing consists	an indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population
a particular kind or species of matter with uniform properties	any stratum or layer lying underneath another
the property of holding together and retaining its shape	a surface on which an organism grows or is attached
the idea that is intended	the substance that is acted upon by an enzyme or ferment
the choicest or most essential or most vital part of some idea or experience
content communicating a message; what something is about
considerable capital (wealth or income)
material of a particular kind or constitution