substance vs chemistry

substance and chemistry both are nouns.

Word	Noun	Adjective	Verb	Adverb
substance	Yes	No	No	No
chemistry	Yes	No	No	No

As nouns, chemistry is a hyponym of substance; that is, chemistry is a word with a more specific, narrower meaning than substance:

substance (noun)	chemistry (noun)
the real physical matter of which a person or thing consists	the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions
a particular kind or species of matter with uniform properties	the way two individuals relate to each other
the property of holding together and retaining its shape	the chemical composition and properties of a substance or object
the idea that is intended
the choicest or most essential or most vital part of some idea or experience
content communicating a message; what something is about
considerable capital (wealth or income)
material of a particular kind or constitution