despondence vs heartsickness

despondence and heartsickness both are nouns.

Word	Noun	Adjective	Verb	Adverb
despondence	Yes	No	No	No
heartsickness	Yes	No	No	No

As nouns, despondence and heartsickness are synonyms defined as:

despondence and heartsickness: feeling downcast and disheartened and hopeless

Other synonyms of despondence include despondency, disconsolateness.

despondence (noun)	heartsickness (noun)
feeling downcast and disheartened and hopeless	feeling downcast and disheartened and hopeless