heartsickness vs despondency

heartsickness and despondency both are nouns.

Word	Noun	Adjective	Verb	Adverb
heartsickness	Yes	No	No	No
despondency	Yes	No	No	No

As nouns, heartsickness and despondency are synonyms defined as:

heartsickness and despondency: feeling downcast and disheartened and hopeless

Other synonyms of heartsickness include despondence, disconsolateness.

heartsickness (noun)	despondency (noun)
feeling downcast and disheartened and hopeless	feeling downcast and disheartened and hopeless