despondency vs despondence

despondency and despondence both are nouns.

Word	Noun	Adjective	Verb	Adverb
despondency	Yes	No	No	No
despondence	Yes	No	No	No

As nouns, despondency and despondence are synonyms defined as:

despondency and despondence: feeling downcast and disheartened and hopeless

Other synonyms of despondency include disconsolateness, heartsickness.

despondency (noun)	despondence (noun)
feeling downcast and disheartened and hopeless	feeling downcast and disheartened and hopeless