fretfulness vs choler

fretfulness and choler both are nouns.

Word	Noun	Adjective	Verb	Adverb
fretfulness	Yes	No	No	No
choler	Yes	No	No	No

As nouns, fretfulness and choler are synonyms defined as:

Other synonyms of fretfulness include crossness, fussiness, irritability, peevishness, petulance.

fretfulness (noun)	choler (noun)
an irritable petulant feeling	a humor that was once believed to be secreted by the liver and to cause irritability and anger
	a strong emotion; a feeling that is oriented toward some real or supposed grievance
	an irritable petulant feeling