gist vs significance

gist and significance both are nouns.

Word	Noun	Adjective	Verb	Adverb
gist	Yes	No	No	No
significance	Yes	No	No	No

As nouns, significance is a hypernym of gist; that is, significance is a word with a broader meaning than gist:

Other hypernyms of gist include import, meaning, signification.

gist (noun)	significance (noun)
the choicest or most essential or most vital part of some idea or experience	the quality of being significant
the central meaning or theme of a speech or literary work	a meaning that is not expressly stated but can be inferred
	the message that is intended or expressed or signified