hypostasis vs substance

hypostasis and substance both are nouns.

Word	Noun	Adjective	Verb	Adverb
hypostasis	Yes	No	No	No
substance	Yes	No	No	No

As nouns, substance is a hypernym of hypostasis; that is, substance is a word with a broader meaning than hypostasis:

hypostasis: (metaphysics) essential nature or underlying reality
substance: the choicest or most essential or most vital part of some idea or experience

Other hypernyms of hypostasis include center, centre, core, essence, gist, heart, heart and soul, inwardness, kernel, marrow, meat, nitty-gritty, nub, pith, sum.

hypostasis (noun)	substance (noun)
(metaphysics) essential nature or underlying reality	the real physical matter of which a person or thing consists
any of the three persons of the Godhead constituting the Trinity especially the person of Christ in which divine and human natures are united	a particular kind or species of matter with uniform properties
the accumulation of blood in an organ	the property of holding together and retaining its shape
the suppression of a gene by the effect of an unrelated gene	the idea that is intended
	the choicest or most essential or most vital part of some idea or experience
	content communicating a message; what something is about
	considerable capital (wealth or income)
	material of a particular kind or constitution