in and of itself vs intrinsically

in and of itself and intrinsically both are adverbs.

Word	Noun	Adjective	Verb	Adverb
in and of itself	No	No	No	Yes
intrinsically	No	No	No	Yes

As adverbs, in and of itself and intrinsically are synonyms defined as:

Other synonyms of in and of itself include per se.

in and of itself (adverb)	intrinsically (adverb)
with respect to its inherent nature	with respect to its inherent nature