intrinsically vs in and of itself

intrinsically and in and of itself both are adverbs.

Word	Noun	Adjective	Verb	Adverb
intrinsically	No	No	No	Yes
in and of itself	No	No	No	Yes

As adverbs, intrinsically and in and of itself are synonyms defined as:

Other synonyms of intrinsically include per se.

intrinsically (adverb)	in and of itself (adverb)
with respect to its inherent nature	with respect to its inherent nature