in and of itself vs per se

in and of itself and per se both are adverbs.

Word	Noun	Adjective	Verb	Adverb
in and of itself	No	No	No	Yes
per se	No	No	No	Yes

As adverbs, in and of itself and per se are synonyms defined as:

Other synonyms of in and of itself include intrinsically.

in and of itself (adverb)	per se (adverb)
with respect to its inherent nature	with respect to its inherent nature