per se vs in and of itself

per se and in and of itself both are adverbs.

Word	Noun	Adjective	Verb	Adverb
per se	No	No	No	Yes
in and of itself	No	No	No	Yes

As adverbs, per se and in and of itself are synonyms defined as:

Other synonyms of per se include intrinsically.

per se (adverb)	in and of itself (adverb)
with respect to its inherent nature	with respect to its inherent nature