nuance vs significance

nuance and significance both are nouns.

Word	Noun	Adjective	Verb	Adverb
nuance	Yes	No	No	No
significance	Yes	No	No	No

As nouns, significance is a hypernym of nuance; that is, significance is a word with a broader meaning than nuance:

Other hypernyms of nuance include import, meaning, signification.

nuance (noun)	significance (noun)
a subtle difference in meaning or opinion or attitude	the quality of being significant
	a meaning that is not expressly stated but can be inferred
	the message that is intended or expressed or signified