quintessence vs substance

quintessence and substance both are nouns.

Word	Noun	Adjective	Verb	Adverb
quintessence	Yes	No	No	No
substance	Yes	No	No	No

As nouns, substance is a hypernym of quintessence; that is, substance is a word with a broader meaning than quintessence:

quintessence: the purest and most concentrated essence of something
substance: the choicest or most essential or most vital part of some idea or experience

Other hypernyms of quintessence include center, centre, core, essence, gist, heart, heart and soul, inwardness, kernel, marrow, meat, nitty-gritty, nub, pith, sum.

quintessence (noun)	substance (noun)
the purest and most concentrated essence of something	the real physical matter of which a person or thing consists
the most typical example or representative of a type	a particular kind or species of matter with uniform properties
the fifth and highest element after air and earth and fire and water; was believed to be the substance composing all heavenly bodies	the property of holding together and retaining its shape
	the idea that is intended
	the choicest or most essential or most vital part of some idea or experience
	content communicating a message; what something is about
	considerable capital (wealth or income)
	material of a particular kind or constitution