run down vs tire

run down is not a noun while tire is a noun.

Word	Noun	Adjective	Verb	Adverb
run down	No	No	Yes	No
tire	Yes	No	Yes	No

As verbs, tire is a hypernym of run down; that is, tire is a word with a broader meaning than run down:

Other hypernyms of run down include fatigue, jade, pall, weary.

As verbs, run down and tire are synonyms defined as:

Other synonyms of run down include exhaust, play out, sap.

run down (noun)	tire (noun)
	hoop that covers a wheel

run down (verb)	tire (verb)
use up all one's strength and energy and stop working	lose interest or become bored with something or somebody
injure or kill by knocking (someone or something) down and passing over the body, as with a vehicle	exhaust or get tired through overuse or great strain or stress
pursue until captured	cause to be bored
move downward	deplete
examine hastily
deplete
trace