subtlety vs significance

subtlety and significance both are nouns.

Word	Noun	Adjective	Verb	Adverb
subtlety	Yes	No	No	No
significance	Yes	No	No	No

As nouns, significance is a hypernym of subtlety; that is, significance is a word with a broader meaning than subtlety:

Other hypernyms of subtlety include import, meaning, signification.

subtlety (noun)	significance (noun)
the quality of being difficult to detect or analyze	the quality of being significant
a subtle difference in meaning or opinion or attitude	a meaning that is not expressly stated but can be inferred
	the message that is intended or expressed or signified